Site‐specific recombination events are of fundamental importance in many biological systems. In vitro experiments using purified proteins and DNA sub‐strates are yielding insights into strand exchange mechanisms and synapsis of recombination sites. By examining results across a range of systems ‐ prokaryotic and eukaryotic ‐ two distinct classes of site‐specific recombinase enzymes can be defined.

Abstract In the present article, we provide a critical overview of the emerging field of ‘neuroeducation’ also frequently referred to as ‘mind, brain and education’ or ‘educational neuroscience’. We describe the growing energy behind linking education and neuroscience in an effort to improve learning and instruction. We explore reasons behind such drives for interdisciplinary research. Reviewing some of the key advances in neuroscientific studies that have come to bear on neuroeducation, we discuss recent evidence on the brain circuits underlying reading, (...) mathematical abilities as well as the potential to use neuroscience to design training programs of neurocognitive functions, such as working memory, that are expected to have effects on overall brain function. Throughout this review we describe how such research can enrich our understanding of the acquisition of academic skills. Furthermore, we discuss the potential for modern brain imaging methods to serve as diagnostic tools as well as measures of the effects of educational interventions. Throughout this discussion, we draw attention to limitations of the available evidence and propose future avenues for research. We also discuss the challenges that face this growing discipline. Specifically, we draw attention to unrealistic expectations for the immediate impact of neuroscience on education, methodological difficulties, and lack of interdisciplinary training, which results in poor communication between educators and neuroscientists. We point out that there should be bi-directional and reciprocal interactions between both disciplines of neuroscience and education, in which research originating from each of these traditions is considered to be compelling in its own right. While there are many obstacles that lie in the way of a productive field of neuroeducation, we contend that there is much reason to be optimistic and that the groundwork has been laid to advance this field in earnest. Content Type Journal Article Category Original Paper Pages 1-13 DOI 10.1007/s12152-011-9119-3 Authors Daniel Ansari, Numerical Cognition Laboratory, Department of Psychology, The University of Western Ontario, Westminster Hall, London, ON N6A 3K7, Canada Bert De Smedt, Parenting and Special Education Research Group, Katholieke Universiteit Leuven, Leuven, Belgium Roland H. Grabner, Institute for Behavioral Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland Journal Neuroethics Online ISSN 1874-5504 Print ISSN 1874-5490. (shrink)

Avant-propos.--Notes: Y a-t-il eu un "avicennisme latin"? Guillaume d'Auvergne témoin de l'"Avicennisme latin." Avicenne et les décrets de 1210 et 1215. Un témoignage de Guillaume d'Auxerre. Un texte d'Albert le Grand. Le cas de Roger Bacon. La date, les sources et la doctrine du "Liber de causis primis et secundis."--Textes: Le "Liber de causis primis et secundis." La fin du "De anima" de Gundissalinus. Tables.

Dementia is highly prevalent and incurable. The participation of dementia patients in clinical research is indispensable if we want to find an effective treatment for dementia. However, one of the primary challenges in dementia research is the patients’ gradual loss of the capacity to consent. Patients with dementia are characterized by the fact that, at an earlier stage of their life, they were able to give their consent to participation in research. Therefore, the phase when patients are still competent to (...) decide offers a valuable opportunity to authorize research, by using an advance research directive. Yet, the use of ARDs as an authorization for research participation remains controversial. In this paper we discuss the role of autonomous decision-making and the protection of incompetent research subjects. We will show why ARDs are a morally defensible basis for the inclusion of this population in biomedical research and that the use of ARDs is compatible with the protection of incompetent research subjects. (shrink)

Blood service organizations employ various ways to ensure transfusion blood safety, including the testing of all donations for transfusion-transmissible infections (TTI) and the exclusion of donors who are at increased risk of a recent infection. As some TTIs are more common among men who have sex with men (MSM), many jurisdictions (temporarily) defer the donation of blood by sexually active MSM. This boils down to a categorical exclusion of a large group solely on the basis of their sexual orientation, which (...) is seen as unduly discriminatory and stigmatizing. Blood service organizations in the U.K. and the Netherlands have recently changed their deferral policies for MSM. The problem of the MSM deferral involves a conflict between fundamental rights: the right of MSM to equal treatment and the right to health of the recipients of blood and blood products. We distinguish and discuss three broad alternative options to the current categorical deferral of MSM donations: (1) completely abandoning donor selection on the basis of sexual behavior, (2) individual risk assessment of the sexual activities of each potential donor, and (3) individual risk assessment of the sexual activities of MSM only. The new U.K. policy falls within the second category, and the new Dutch policy is in the third category. We argue that each approach comes with moral costs but that the most reasonable option is different from the policies of both the U.K. and the Netherlands. (shrink)

Après un premier volume, A l'Orient de Michel Henry (2014), cet ensemble de textes poursuit la quête d'une définition de la vérité comprise comme subjectivité vivante, comme cette épreuve de soi qui conditionne et transite ensuite l'ensemble des expériences et des savoirs qui sont les nôtres. Il apparaîtra, ce faisant, le caractère éminemment concret des catégories mises en oeuvre par Michel Henry et comment elles peuvent s'appliquer à de nombreux domaines d'existence, étant capables d'en rendre compte avec cette pertinence et (...) cette puissance explicative que permet seul leur ancrage dans le fondement vivant qui les informe secrètement sous l'apparence des choses. (shrink)

L'interrogation du phénomène esthétique est contemporaine de l'autonomisation de l'art au cours des Temps modernes et de la relativisation de sa fonction lorsqu'il n'est plus que le moyen d'exprimer la vie émotionnelle subjective. En revanche, lorsque la singularité même de l'œuvre d'art se voit mise en question au XXe siècle, ce sont les frontières séparant l'art du non-art qui deviennent évanescentes. C'est sur le fond de cet évènement que s'est déployée la réflexion de Roland Quilliot, que les contributions de (...) ce recueil se proposent de poursuivre. Celles-ci reviennent sur la notion d'image puis sur la manière dont elle se déploie du côté de la littérature comme des arts plastiques y compris du cinéma. Le second temps du recueil s'inscrit, lui, dans le cadre d'une réflexion relative à la crise de l'art moderne, en suggérant aussi que le phénomène esthétique demande à être considéré dans un cadre moral et anthropologique bien plus englobant. (shrink)

La parabole du vieux et du neuf selon Luc est pratiquement toujours considérée comme faisant partie de la controverse sur le jeûne ; ce qui limite fort son interprétation. En réalité c'estune péricope à part entière et son contexte est formé par l'ensemble des controverses avec les pharisiens : à propos du paralysé pardonné et guéri, puis chez Lévi à propos de la conduite de Jésus envers les pécheurs et le jeûne; puis, après la parabole, à propos des épis froissés, (...) puis de la guérison de l'homme à la main paralysée, toutes deux le sabbat. Centrale, la parabole est la clé de lecture de toute la séquence: la nouveauté est celle de la «nouvelle alliance» annoncée en particulier par Jérémie. Celle-ci repose sur le pardon des péchés, mis en acte dès le début. Sa figure est celle des épousailles; or Jésus se présente comme l'Époux. Ce qui est en question n'est autre que la Loi, représentée dès le début par ses Docteurs, cristallisée en finale dans le sabbat. (shrink)

Theory suggests that stimulus evaluations automatically evoke approach–avoidance behavior. However, the extent to which approach–avoidance behavior is triggered automatically is not yet clear. Furthermore, the nature of automatically triggered approach–avoidance behavior is controversial. We review research on two views on the type of approach–avoidance behavior that is triggered automatically (arm flexion/extension, distance change). Present evidence supports the distance-change view and corroborates the notion of an automatic pathway from evaluation to distance-change behavior. We discuss underlying mechanisms (direct stimulus–response links, outcome anticipations, (...) goals) as well as implications regarding the flexibility of the evaluation–behavior link. (shrink)

Roland Barthes' renowned and never before translated lectures pursue a central theme in his work, namely the quest for the neutral.

A collection of texts by representative French materialist philosophers, including the Baron d'Holbach, Denis Diderot, Sylvain Maréchal, the Marquis de Sade, Jean-Baptiste Robinet, Pierre Jean Georges Cabanis, Claude Adrien Helvétius, and various others.

To what extent do differences in who we are predict differences in courage? We propose to de-velop a measure of the virtue-relevant self, which is composed of self-conception, social roles, virtue-relevant values, and personality traits. We will then conduct three studies using this meas-ure to determine the extent to which these various components of the virtue-relevant self pre-dict the types of acts people consider courageous as well as the willingness of people to engage in courageous acts themselves. We believe that (...) individual differences in each of these compo-nents – that is, the content of the virtue-relevant self – will correlate with differences in first, how people rate actions that they themselves have undertaken in the past; second, how people rate actions that other people have taken; and third, the willingness of people to take certain kinds of courageous action. If found, these relations will have broader implications for the self and virtues by indicating that traits of the self beyond character traits affect both the conception of virtuous behavior and virtuous behavior itself. (shrink)

Definition of the problem: Contemporary bioethics as an academic discipline mainly focuses on moral questions – according to its articulated self-concept and the explicit arguments in most areas of bioethical reflection. Concepts and theories of the good life are hardly considered. Arguments: In reality the ‘good life’ plays a much more important role than it is assumed, but mostly only in an implicit way. The article demonstrates this by referencing three selected fields of bioethical discussion. Hence the article argues that (...) bioethics should turn the ‘good life’ into an issue of intense, explicit and systematic consideration. Furthermore, the article provides an initial answer to the questions as to why the ‘good life’ has been marginalized within bioethics up to this point and which function it can assume in future bioethical reflection. Conclusion: The ‘good life’ is the blind spot of bioethics. A more intensive and systematic consideration of the ‘good life’ is a challenge for contemporary and future bioethics. (shrink)